Brand from Japan: POLA. Contains POLA ORBIS Group's original ingredient Nil One R, which was the first in Japan to be recognized as an active ingredient in quasi-drugs that improves wrinkles.It also adopts a new dynamic delivery formula, and the active ingredient Neil One* penetrates deep into the dermis of the skin to improve wrinkles.How to use:Use after preparing your skin with lotion during your daily morning and evening care.Take the serum on your fingertips and apply an appropriate amount to the areas where you are concerned about wrinkles.Approximate amount to use per area (both corners of the eyes, both wrinkles around the mouth, forehead, etc.) is about 2 grains of rice.Gently apply in the direction of the arrow as if stretching the wrinkles.Spread from the inside to the outside and from the bottom to the top.Gently apply around the eyes (eyelids and under the eyes) from the inner corner of the eye to the outer corner of the eye.